Quinolines and derivatives

TARGETMOL CHEMICALS INC Cefaclor monohydrate 200MG

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Also available in 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Cefaclor monohydrate (Cefaclorum) is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Purity 99.48%

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Medchemexpress LLC DGAT1 Human Pre-desi 1set | 1SET

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DGAT1 Human Pre-desi 1set | 1SET

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Medchemexpress LLC JNK-IN-8 (JNK Inhibitor XVI) | 1410880-22-6 | 99.7% | 507.59 | 200 MG

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JNK-IN-8 (JNK Inhibitor XVI) is a potent inhibitor of JNK, demonstrating IC50 values of 4.7 nM for JNK1, 18.7 nM for JNK2, and 1 nM for JNK3. It inhibits the phosphorylation of c-Jun, a direct substrate of JNK kinase, with EC50s of 486 nM in HeLa cells and 338 nM in A375 cells. This compound also exhibits exceptional selectivity, as evidenced by KinomeScan and enzymatic profiling, making it a suitable tool for investigating JNK-dependent biological phenomena. JNK-IN-8 is a selective pan-JNK inhibitor that covalently targets Cys154 via an N,N-dimethyl butenoic actemide warhead.

• Potent JNK inhibitor with IC50s: JNK1 (4.7 nM), JNK2 (18.7 nM), and JNK3 (1 nM).
• Inhibits phosphorylation of c-Jun.
• Demonstrates high selectivity based on KinomeScan and enzymatic profiling.
• Covalently targets Cys154 through an N,N-dimethyl butenoic actemide warhead.

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Medchemexpress LLC N-allyl-6-bromoquinazolin-4-amine | 307538-42-7 | MFCD02166825 | 99.9% | 264.12 | C11H10BrN3 | 200 MG

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SMER28 is a small-molecule positive regulator of autophagy that operates via an mTOR-independent mechanism and has been reported to reduce accumulation of amyloid beta peptide. It is supplied as a research reagent in solid and solution forms for use in cellular and biochemical studies.

• Positive regulator of autophagy via an mTOR-independent pathway.
• Reported to prevent accumulation of amyloid beta peptide.
• Suitable for in vitro cellular and biochemical autophagy studies.
• Available in multiple package formats including solid and DMSO solution for assay flexibility.
• Characterized by a defined molecular formula and molecular weight for reproducible experiments.

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Apexbio Technology LLC AM-095 free base 1228690-36-5 200mg

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AM-095 free base (CAS 1228690-36-5) is an orally bioavailable antagonist of lysophosphatidic acid receptor 1 (LPA1) It demonstrates inhibitory activity against recombinant human and mouse LPA1 with IC50 values of 0 98 M and 0 73 M respectively In vitro AM-095 suppresses LPA1-mediated chemotaxis in both mouse LPA1/CHO cells (IC50 0 78 M) and human A2058 melanoma cells (IC50 0 23 M) In murine models it blocks LPA-induced histamine release and reduces collagen and protein levels in bronchoalveolar lavage fluid with ED50 values of 8 3 mg/kg and 10 mg/kg respectively Additionally AM-095 decreases macrophage and lymphocyte infiltration in bleomycin-induced lung injury models supporting its utility in studies of LPA1-mediated fibrotic and inflammatory processes

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Medchemexpress LLC Cytochrome c (bovine heart) | 9007-43-6 | MFCD00130890 | 95.0% | 12,327 Da | 200MG

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Cytochrome c (bovine heart) is a heme-containing mitochondrial protein provided as a lyophilized powder for research use. It functions in electron transport and is commonly used as a reagent or standard in biochemical assays of oxidative phosphorylation, electron-transfer reactions, and apoptosis research. The material is characterized by its protein sequence and heme prosthetic group and is supplied at ~95% purity.

• Heme-containing mitochondrial protein suitable for biochemical studies.
• Commonly used as a reagent or standard in electron transport and apoptosis assays.
• Provided as a lyophilized powder for convenient storage and handling.
• Purity approximately 95.0% as listed by the manufacturer.
• Available in multiple pack sizes, including a 200 mg pack.
• Identified by CAS number 9007-43-6 for reference and traceability.

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Selleck Chemical LLC Mefloquine HCl S4420-500mg

Mefloquine HCl(Mefloquin hydrochloride) is a blood schizonticide by inhibiting hemozoin formation used as an antimalarial drug

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Medchemexpress LLC N,S-diacetyl-L-cysteine | 18725-37-6 | 99.4% | 200MG

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N,S-diacetyl-L-cysteine | 18725-37-6 | 99.4% | 200MG

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Apexbio Technology LLC GNF-5837 1033769-28-6 200mg

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GNF-5837 (CAS 1033769-28-6) is a potent and selective pan-Trk inhibitor exhibiting inhibitory activity against TrkA and TrkB with IC50 values of 8 nM and 12 nM respectively In cellular assays GNF-5837 suppresses proliferation in TRKA/NGF-expressing Ba/F3 and RIE cells with IC50 values of 0 042 M and 0 017 M respectively The compound has also been shown to inhibit c-Kit and PDGFR in select cell models In vivo GNF-5837 demonstrated dose-dependent tumor inhibition in xenograft mouse models derived from TRKA/NGF-expressing RIE cells Its oral bioavailability and specificity make it a valuable tool for investigating TRK signaling in oncogenic processes and other disease models No clinical evaluation has been reported to date

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